Mitochondria are great little organelles. Looking over some archival electron micrographs, isolated mitochondria from hepatocyte with a gradual post-natal knockout of a gene critical to glutathione synthesis (details) can be found in Y. Chen’s publication. So I am looking for changes in mitochondrial shape in isolated preps that might relate to oxidative stress, but confess that I am also on the hunt for mtDNA, and anything that would resemble a  type of mtDNA protein complex, like the nucleoid present in yeast mitochondria. Nothing in this micrograph but I did find a curious pattern of small densities which I have boxed and highlighted in the inset.

Here is a micrograph from isolate mitochondria in the hepatocyte specific Gclc ko mouse.  Post natal day 21, h/h + N-acetyl cysteine (NAC). Neg 18315, block 78177, 20,000x. Tiny black bar in original unretouched = about 25 nm, and also in the enlarged and dot-emphasized inset. I wonder what that organization might be, but not mtDNA alone, but possibly little complexes?