This is a quick observation perhaps meaningful (well i think it is relevant to the interaction of perfluorodecyl iodide within the lysosome). It appears to me like the inner lysosomal membrane is quite a bit thinner (meaning probably 1) a difference in the lipid membrane constituents or 2) the loss of some of the intrinsic membrane proteins.  I measured just one area of such a lysosome, and the outer lysosomal membrane seems to be about twice as thick as that which abuts the perfluorodecyl iodide crystalline inclusion.

blue perfluorodecyl iodide “footprint’, ribosome=red dot, green bar is the thickness of the inner membrane of the lysosome, dark blue is the thickness of the outer lysosomal membrane. Insert area is shown by white box, and red ribosome is shown with in the inset and the original box. liver (hepatocyte), neg 9716, block 3775, IPFD 100cc/kg (mouse) 9 months recovery