The LAMP family is characterized by a conserved domain of 150 to 200 amino acids with two disulfide bonds. While reading this I looked up one of the references to see what they had pointed out as the morphological differences between endosomal membranes and lysosomal membranes and found this diagram in the publication linked here. While is seems trivial in a sense, it is not really, since visual depiction of facts needs to be as accurate as verbal depiction of facts… otherwise it is “fake science news”.  The diagram below goes against everything I have learned about cell biology…. with the arrow on the bottom pointing FROM the lysosome, TO the early endosome….  what? The early endosome is the beginning, by their own words  statement the early endosome is created de novo at the cell membrane.  So then I ask, why is the arrow not pointing in the other direction? and here is a quote “Endocytosed material tends to flow vectorially through the system, proceeding through the early endosome, the endosome carrier vesicle, the late endosome and the lysosome.” speaking to this subject.