I don’t have a lot of data about the inclusions in this “apparent” alveolar macrophage (my best guess) but the round droplets seen at the left are perfluorochemical emulsion particles which is typical of what was seen in many species after intravenous infusion of such emulsions during studies on blood substitutes during the 1970s. This nucloeus caught my attention because I though perhaps I was going to find more “ring or donut” shaped nucleoli, but on closer look this area within the nucleus is infact a slightly curved invagination certainly caused by the pressure of one a smallish perfluorophenanthrene droplet on the side of the nucleus just below the section. Inset to right shows the nuclear pores which have been tantentially sectioned confirming that it is not nucleolus.
The range in size of perfluorocarbon droplets within cells is pretty amazing, and can range from sub-micron size to hundreds of microns in diameter. Size of particles plotted against time were related in some way to the off-gassing of the PFCs.The widest medical use for perfluorochemicals today seems to be in ocular procedures for the detached retina (vitreous replacement?). Not for me. no thanks. Silicon oil would not make me any happier.