I don’t know why the collgaen-like domain of SP-D keeps being labeled “disordered”  It is highly ordered as seen in shadowed and AFM images. This confuses me.

See red line area midway down under the section “disorder”. Aside from the fact that the collagen like domain is “ordered”, the idea that “disorder” exists in any of these highly specific and well adapted, and very old proteins is just a little naive. Kind of like looking back in retrospect at the guy who first coined the term “junk DNA”  ha ha.  Not gonna be so, ha ha, and reflects lack of knowledge rather than any biological disorder.

Reminds me of a lecture by the Late Dr. Ernest Foulkes, way back in the 1980s when he was working on metals and kidney function. I remember so clearly his statement, when the kidney was overwhelmed by whatever metal treatment he had given, said… “looks like bad design”  EYE ROLL.  ha ha… like he could have come up with something better than what nature devised over millions and millions of years.  Also, not gonna happen.