Alveolar type II cell RER inclusions: two different proteins? two different organizations

THis particular alveolar type II cell (from one of my most favorite guinea pig blocks, i.e. # 301, comes this profile in which there are two enormous RER bodies (at this point I don’t think it is fair to call them granules, but something else, I don’t know what) which are upwards of 20-30 microns across.  One (on the right – see inset box) has the organization of a usual intracisternal body or granule that I have repeatedly found in guinea pig, at least the animals that were in our experimental group back in the 1980s) and the other does not.  I am not bold enough to call this a separate surfactant protein type of granule (as opposed to what i think the right hand granule is, that is, surfactant protein A) but it certainly has its own unique banding.

9817_17084_gpig_301_two_ICB