I have not really found the equivalent of the electron dense particles in the RER of Gclc mice (posted yesterday) for conditional liver ko animals rescued with NAC at 60d. I have also not found an equivalent (googling and other pathology type searches) for the iron spicules found within those partially RER vesicles.   However I did come close to finding a match for the vesicles within vesicles (though these cells were in vitro, not liver, and not in vivo). The partial publication URL which shows iron particles (USPIO nanoparticles at iron concentrations of 50 μg/ml)(link here) which are NOT LIKE the spicules found in the mice I am looking at, but does show something like the vesicular changes, that is, the vesicle-within a vesicle configuration.

I have pseudocolored the vesicles to compare orange, and on the left is the image from the Gclc conditional ko rescued with NAC, and on the right is the cell line (Canine ADSCs or canine adipose derived stem cells) treated by these researchers with iron.  Red arrows point to the vesicles within vesicles, black arrow from their micrograph point to nanoparticles of iron.  Heavy metal (maybe iron in left hand micrograph) looks like a fuzzy black iron filing mass pulled by a magnet into a glump, very different from the iron in the micrograph on the right. It is critical to point out that the vesicles are pretty much ribosome free, while those RER bound objects with electron dense (presumptive iron) have ribosomes, at least over part of their surface.

Here is another example of metal (in this case aluminum) in tissue culture forming dense lysosomal bodies.