Alveolar type II cell in rat: vinyl chloride and vitamin C

I am posting this not really as a huge project, but just as a reminder to self, and to those interested that sometimes data are lost and forgotten but can still have meaning. The study mentioned here was just part of a very large study which was conducted by a good friend (late, actually many years passed on) who was very careful in what she did, and didn’t press conclusions or publications beyond their real findings. She was also a good friend.  Dr. Martha Radike (who did these inhalation experiments at the University of Cincinnati, College of Medicine, Department of Environmental Health, back in the 1980s.  The test animals  (160 male Hartley guinea pigs) represented significant effort.  I did some of the electron microscopy but never completed a manuscript on the animals (and they represented only 18 out of the sum total of the experiment.

My interest in the guinea pigs was revitalized while doing a bigger review of over 1400 micrographs looking specifically for a granule of surfactant protein in alveolar type II cells.  So this study I brought up out of the archives for that purpose and found a summary, which I have posted HERE as a pdf for anyone who is interested.  vinyl_chloride_vit_C_guinea_pig_lung

Here is an enlarged image from that pdf.

vinyl_chloride_vit_C_guinea_pig_lung