A single isolated mitochondrion (blue) and attached SER (pink) from a mouse at D28, likely isolated from liver, postnatally having received NAC. This and other images were of controls for D28 mitochondrial pellets from hepatocyte specific GCLC ko mice also receiving NAC. There is a lot of substructure going on at the attachment between the outer mitochondrial membrane and the SER membrane, and some tiny cristae right at that junctional tether. It is possible that a mitochondrial ribosome is in the field as well (dark dot rounded object in mitochodnrial matrix – middle right. (also there is a tiny piece of dirt, so dont be confused). So the periodicity between SER and mitochondrion seems to come out at about 35nm which is larger than I had hoped, but there is always the possibility that the structures were cut tangentially.
Monthly Archives: July 2018
Pineapple and swiss cheese
Who knew? Ha ha… after a sleepless itchy night of tossing and wondering and trying to figure out what in the world triggered this insomnia i remembered two things that I had eaten late evening and before bed. Fresh pineapple and swiss cheese. I googled it, and found some interesting stuff, some stuff from well known nutritional voices, that there are people who are sensitive to “amines”. So i already knew this, i never drink wine because of the amines (actually I learned that in my 20s that only gin did not give me puffy eyes and a hangover, i don’t really drink anything now) and i had an idea that cheese might not be something to eat late at night.
But what I found was that “ripened cheeses…like swiss” can have a LOT of amines – histamine in particular – and this depends upon how long it is aged and other things and it can vary quite a bit between products and between batches…. OK so no more cultured cheese in the early evening so I don’t have so much circulating histamine, but what i also found was that pineapple (who knew) releases histamine. Ha ha… double bad…. lots of amines by swiss cheese, lots of histamine release by pineapple.
If you have some amine (i guess this might include glutamine) sensitivity, and you eat a lot of pineapple and cultured cheese before bed, then you might have that “restlessness” and “sleeplessness” that feels a lot like MSG overload.
Just a heads up for those of you who, like myself, might have an “itchy” disease like lichen planus…. and you are already dealing with itching…. you don’t want to increase the amount of histamine you take in or release……!!!
G protein, GPCR, GDP and GTP diagram from wikipedia
Wikipedia post (thank you wikipedia) with this diagram about G protein, G-protein coupled receptor GDP and GTP I thought was pretty good. “Activation cycle of G-proteins (purple) by a G-protein-coupled receptor (GPCR, light blue) receiving a ligand (red). Ligand binding to GPCRs induces a conformation change that facilitates the exchange of GDP for GTP on the a subunit of the heterotrimeric complex. Both GTP-bound Ga in the active form and the released Gßgamma dimer can then go on to stimulate a number of downstream effectors. When the GTP on Ga is hydrolyzed to GDP the original receptor is restored.”
Seven Deadly Sins: Seven Successful Advertising Tricks
Listening to Dr. Ed Young and he mentioned that the seven deadly sins (also known as the capital vices or cardinal sins) were precisely what advertisers use to lure individuals into making purchases. I have felt this for a long time… but this was nicely put by him…. sermon you can find online (July 1 2018).
PRIDE ENVY GREED SLOTH LUST WRATH GLUTTONY (PEGSLWG)(WEGSLGP)(PWEGSLG)(GPGLEWS)(SLEGWEP)(LEGSWGP)(PLEGWGS)(LEWPGGS)(WEGGSPL) — (SPLEGAW) Change wrath to anger–I guess thats not good, since wrath has a “retribution” connotation.
LATIN / ENGLISH
luxuria / Lust /
gula / Gluttony /
avaritia / Greed /avarice
acedia / Sloth / not caring
ira / Wrath / anger with retribution
invidia / Envy /
superbia / Pride