Innocent until proven guilty: True until proven false: The presumption of innocence I guess Trump has turned into the presumption of truth – whether or not his facts are checkable, or whether it is a flit of his imagination. This poses problems for most individuals, because the amount of work required to “undo” one of Trumps accusations is enormous, and who has the time to Snope, FactCheck, JustTheTruth what he tweets or states. The first premise ‘innocent until proven guilty’ is brilliant, saves lives, though does let a few criminals go, but protects us against a State where we are all in jeopardy. However, living by the second premise requires that everyone be as honest as possible, out of their own moral goodness, and of course we all know that is not happening in this epoch. So when Trump (given here as an example and which has been seen on numerous occasions, and for whom truth seems a distant non-reality) says something in a tweet (which is a fart…. see previous post about tweets ) we have to go through countless steps, spend countless dollars, waste countless amounts of committee time, and get nothing in return except the gratification that he was delusional. It is going to occupy so much time in the next four years, and cost so much of our own money that ultimately we must decide whether we need to just send him off to go tweet his alternative facts or make him hoe a straight row. We will all be the poorer, in so many ways because of his lack of frontal lobe discretions.
Monthly Archives: March 2017
A “tweet” is like a fart
Think about it. Tweeting is not really communicating it is just letting off steam. It has no immediate value, has no on-the-spot response from a foe, or friend, or other individual, it is meant for no-one, and everyone. It is a dumb idea. That doesn’t mean it isn’t popular, it just means that a lot of people like dumb things.
Trump tweets a lot because he eats a lot of food which cause gas apparently.
A better fit model for langerin and profiles of Birbeck granules
Lots of images have been published for Burbeck granules. I am interested in them only because they seem to be the only other C-type lectin which has a substructure that is organized and obvious when viewed with electron microscopy. Well not the only, because I think that SP-D has fuzzy ball structure that is seen with TEM. It is puzzling why MBP and some other lectins don’t assemble into orderly granules like langerin, and SP-A (at least I think it is SP-A).
So here is a composite that I have made from TEMs posted everywhere in the literature, lined up with the 50 nm distance between the ER membranes, and such a very predictable substructure of proteins organized within. One publication in Plos ONE (Glycosaminoglycans Are Interactants of Langerin: Comparison with gp120 Highlights an Unexpected Calcium-Independent Binding Mode. Eric Chabrol, Alessandra Nurisso, Antoine Daina, Emilie Vassal-Stermann, Michel Thepaut, Eric Girard, Romain R. Vivès, Franck Fieschi) gives a molecular structure and a hypothetical overlay onto TEM images. I think they missed it by a little…. for starters their intramembrane part of the molecule is NOT shown in their diagrams, which makes the molecular fit difficult since the CRD of the molecule are a relatively larger portion of the actual TEMs than is seen in their molecular diagram (line diagrams on the far right of the image). Additionally, there is a cytoplasmic portion of langerin, at opposite ends of the mirrored CRD portions of langerin which their diagram does not show (don’t know why they chose not to show it).I vectorized their diagram and have placed it back in the 50 nm membrane boundaries of the ER with the transmembrane portions actually existing and that makes the size ration of the model molecule fit the actual TEM much better.
Again, my only interest in this is that I am trying to ascertain whether my thought that SP-A is responsible for the granule in guinea pig and ferret type II alveolar cells true.
Right side of the diagram is a collection of Birbeck granule TEMs sized to 50 nm, the image on the right shows a red 50 nm bounding box, and four langerin molecules oriented CRD inward, and transmembrane areas through the ER membrane. Just my opinion here but there is another molecule or some portion of langerin which is “between” the four diagrams superimposed. White arrows point there. Their diagrams (two alternatives) are shown in red and grey to the right of the actual TEMs of Birbeck granules.
Medical mistakes
This post is just a reminder that MDs just don’t know it all.
The Hippocratic oath is to DO NO HARM but by doing things to patients without complete knowledge of certain outcomes of treatment does do harm. Of course it is understood that we live in an infinite universe, we try to be scientific, however, there are times that treatment becomes the “easy” button rather than a more conservative, longer lasting, patient guided approach.
Case: (from my perspective) Anxious male early adult. Self induced and MD induced remedies. Tobacco, alcohol, xanax, poor diet, little interest in exercise. Chronic fatigue, depression, continued substance abuse and lethargy for 30 years. Outcome: chronic cough, confusion, lethargy, type II diabetes, high blood pressure, drug dependence, incontinence, pancreatic cancer, chemo-induced lack of appetite and energy. I blame the MDs, largely, because the appropriate treatment would have been counseling, support, and education. Yes we need free will, but we don’t need enabling, especially when the enabling causes such loss of quality of life. We don’t need health-care reform as much as we need to reform our approach to health care.
“health care providers are still advised to avoid benzodiazepines in older adults to prevent important adverse health outcomes, withdrawal and dependence.”
“Benzodiazepines, Class Of Drugs Including Xanax, Linked To Increased Dementia Risk”
“Based on the strength of available evidence regarding diet and lifestyle in the prevention of type 2 diabetes, it is recommended that a normal weight status in the lower BMI range (BMI 21 – 23) and regular physical activity be maintained throughout adulthood; abdominal obesity be prevented; and saturated fat intake be less than 7% of the total energy intake”
“For instance, many anti-anxiety drugs commonly prescribed to seniors such as Valium and Xanax, have side effects that are indistinguishable from Alzheimer’s or dementia, including: Short-term memory loss — Disinhibition — Hallucinations”
“hundreds of dangerous drug interactions with Vyvanse and other drugs; with Zoloft and other drugs; with Xanax and other drugs; with Adderall and other drugs”
The number of sites and references to drug-drug interactions is enormous. I would think that the most intelligent approach to all those nasty feelings, and pains, and upsets that everyone on the planet feels every single minute of every single day, need to be dealt with in some way other than prescription drugs. The BODY has a HEAD and the HEAD has a BODY, and the two better learn to work together for the benefit of both. Who said “heal thyself” they were really really smart, and also pretty dead on right.
Simple truth? Truth is simple and its not here
Simple truth? Truth is simple and its not here. Who makes a brand, like Simple Truth, and then pulls this stunt. Here is a can of beans… before even a single bean was removed… check out how much head space… no beans, Kroger, space !!! … ha ha… The Simple Truth is that here there is is no truth, plain and simple.
Humpty trumpty tweets to us all
Humpty trumpty
tweets to us all
that sets up trumpty
for a great fall
all his supporters
and congressmen
could never put trumpty
together again
I thought i was first, but hosts (yes many many) of humpty dumpty, and dumpty trumpy, and trumpy dumpty quotes out there here is a link to a particularly nice one from Mad magazine
Surface area LUNGS vs GUT
Some time ago i posted a newsletter for a breast cancer grant which mentioned how critical food is, since it is our largest surface area in contact with the environment. I have seen many conflicting opinions (just now, Regulation of surfactant secretion in alveolar type II cells Alexandra V. Andreeva, Mikhail A. Kutuzov, Tatyana A. Voyno-Yasenetskaya
American Journal of Physiology – Lung Cellular and Molecular Physiology Published 31 July 2007 Vol. 293 no. 2, L259-L271) which claimed that lungs were the greatest surface area, but other sites do not concur. They give 100-120 meters sq. Other refs give the square meters of gut at closer to 300. This reference (Herbert F Helander, Lars Fändriks. Surface area of the digestive tract – revisited. Scandinavian Journal of Gastroenterology, 2014; 1 DOI: 10.3109/00365521.2014.898326) gives a smaller value…. I THINK THEY FORGOT THE TENS OF BILLIONS OF MICROVILLI that are present at the apical membrane of each of the enterocytes, especially in the small intestine. This would be easy since they did not look with the electron microscopy, then did these calculations radiologically (kind of like hitting it with a hammer)… I have looked at both, I am sticking with the concept that total surface area in the but is way more than lung…. exact dimensions…. well… that is yet to be decided, but as an electron microscopist… you know my guess… ha ha.
Mutate, blend or die
One of my favorite biological sayings, which i made into a kind of graphic blend of animals organisms and text, is this — Blend, Mutate, or Die — or Mutate bland or die. It is the harsh reality of our world, and maybe all worlds, that is, that inflexibility spells doom, yes, but also spells change. I wont make any political references here, but there are certainly some that could be made.