Daily Archives: November 9, 2016

Does the vitro replica of surfactant speak to SP-A and B participation in the alveolar type II cell granules?

So do you think that SP-A is the main protein component of the alveolar type II cell granule? SP-B has been shown to work with SP-A in several circumstances and particularly in forming tubular myelin lattice structures. SP-B is a pretty small and flat molecule (but not as flat as DP-C, and it diagrams seem to place it wort of “surface-wise) to the plasmalemma bilayer. and if i remember right, maybe the bilayer elements of the alveolar space. Here is a cut and paste from a paper from the “before times” by Williams et al, 1991, where they show artifically created showing some lamellar ultrastructural similarities with the two dense lines and central punctate line seen in RER granules of alveolar type II cells. (but I am not sure about size) thought the mention of 20 nm is there, because i don’t know if that is a measurement from one dense lipid layer to the center punctate line, or all the way across the lamellae. Her reference is HERE.  and a cropped figure from her publication is below. The match is certainly not perfect, but suggestive of possible structural organization of SP-A and lipid.

in_vitro_surfactant-lipids_and_SP-A

I AM EMBARRASSED TO BE AN AMERICAN: an uneducated, low income, male, middle aged, bigoted, self-serving, supremacist society.

HERE< THIS TELLS IT ALL  ha ha

THERE IS STILL HUMOR!

LONDON (The Borowitz Report)—The theoretical physicist Stephen Hawking angered supporters of Donald J. Trump on Monday by responding to a question about the billionaire with a baffling array of long words.

Speaking to a television interviewer in London, Hawking called Trump “a demagogue who seems to appeal to the lowest common denominator,” a statement that many Trump supporters believed was intentionally designed to confuse them.

Moments after Hawking made the remark, Google reported a sharp increase in searches for the terms “demagogue,” “denominator,” and “Stephen Hawking.”

“For a so-called genius, this was an epic fail,” Trump’s campaign manager, Corey Lewandowski, said. “If Professor Hawking wants to do some damage, maybe he should try talking in English next time.”

Later in the day, Hawking attempted to clarify his remark about the presumptive Republican Presidential nominee, telling a reporter, “Trump bad man. Real bad man.”